近日，司法鑒定科學(xué)研究院嚴(yán)慧課題組許琳灝老師，使用IPHASE品牌產(chǎn)品：人肝微粒體在《Journal of Analytical Toxicology》權(quán)·威期刊上發(fā)表文章《In vitro and in vivo metabolic study of three new psychoactive β-keto-arylcyclohexylamines 》，影響因子2.5！
 

　　本論文中，利用斑馬魚和人肝微粒體建立體外和體內(nèi)模型，研究了三種苯換利定類物質(zhì)的體外和體內(nèi)代謝，采用液相色譜-高分辨率質(zhì)譜法分析一相和二相代謝物，總共鑒定出49種代謝物。
 

　　摘要
 

　　Since the 2000s, an increasing number of new psychoactive substances have appeared on the illicit drug market. β-ketoarylcyclohexylamine compounds play important pharmacological roles in anesthesia; however, because these new psychoactive substances have rapidly increasing illicit recreational use, the lack of detailed toxicity data are of particular concern. Therefore, analysis of their metabolites can help forensic personnel provide references and suggestions on whether a suspect has taken an illicit new psychoactive β-keto arylcyclohexylamine. The present study investigated the in vitro and in vivo metabolism and metabolites of three β-ketoarylcyclohexylamines: deschloro-N-ethyl-ketamine, fuoro-N-ethyl-ketamine and bromoketamine. In vitro and in vivo models were established using zebrafsh and human liver microsomes for analysis of Phase I and Phase II metabolites by liquid chromatography–high-resolution mass spectrometry. Altogether, 49 metabolites were identifed. The results were applied for the subject urine samples of known fuoro-N-ethyl ketamine consumer screen analysis in forensic cases. Hydroxy-deschloro-N-ethyl-ketamine, hydroxy-fuoro-N-ethyl-ketamine and hydroxy-bromoketamine were recommended as potential biomarkers for documenting intake in clinical and forensic cases.
 

完整版文獻(xiàn)可在【IPHASE】公眾號(hào)后臺(tái)留言【獲取文章】
 

　　再次恭喜文獻(xiàn)發(fā)表，以及對(duì)我司產(chǎn)品的認(rèn)可，希望以上文獻(xiàn)能幫助大家了解目前研究進(jìn)展及我們的核心技術(shù)，歡迎各位新老客戶聯(lián)系我們咨詢、提出意見(jiàn)，愿我們的努力成果與您的科研碰撞出不一樣的火花！
 

　　發(fā)    文    章    得    獎(jiǎng)    勵(lì)
 

　　凡使用本公司產(chǎn)品，在國(guó)內(nèi)及國(guó)際刊物上發(fā)表論文(論文發(fā)表日起一年內(nèi))，并注明產(chǎn)品屬于IPHASE BIOSCIENCES Co.,Ltd. / 匯智和源生物技術(shù)(蘇州)有限公司所有，即可申請(qǐng)獎(jiǎng)勵(lì)。根據(jù)發(fā)表刊物影響因子不同，給予不同金額獎(jiǎng)品：
 

　　非SCI論文及IF≤5分，500元禮品；
 

　　5分

　　8分

　　IF≥10分 2000元；
 

　　注：禮品卡也可兌換同等金額產(chǎn)品購(gòu)買抵用券；
 

　　活動(dòng)多多，禮品豐厚，快來(lái)參與吧！
 

　　關(guān)    于    我    們
 

　　匯智和源，致力于為創(chuàng)新藥研發(fā)企業(yè)及生命科學(xué)研究機(jī)構(gòu)提供高品質(zhì)的生物試劑，IPHASE為公司核心品牌，品牌宗旨“Innovative Reagents For Innovative Research”。